![]() ![]() alpha-2 globulin suggestive of protein loss pattern due to. IgA, IgM, and sometimes IgG, along with complement proteins, also can be identified in the beta fraction. Serum protein electrophoresis (SPEP) and urine protein electrophoresis (UPEP) are routinely. Beta1 is composed mostly of transferrin, and beta2 contains beta-lipoprotein. The beta fraction has two peaks labeled beta1 and beta2. In general, alpha and gamma globulin protein levels increase when there is inflammation in the body. In myeloma, large amounts of a single antibody are noted as a monoclonal immunoglobulin spike or monoclonal spike (M spike), indicating that the protein came from cells that originally started as single, malignant cell. Just as there are different types of globulins, there are different types of globulin tests. Serum protein electrophoresis (SPEP or SPE) is a laboratory test that examines specific proteins in the blood called globulins. A major disadvantage of serum protein electrophoresis is that it cannot detect an M protein in very low. They are made in your liver by your immune system. An M protein appears as a narrow spike on the agarose gel and should be distinguished from the broad band seen in polyclonal gammopathies associated with cirrhosis and chronic infectious and inflammatory conditions, among others. Globulins are a group of proteins in your blood. Interpretation of elevation, decreased, or visual change in different fractions can be used as a diagnostic aid for a variety of different disease states and protein abnormalities, including monoclonal gammopathies (MG). Globulins comprise a much smaller fraction of the total serum protein but represent the primary focus of interpretation of serum protein electrophoresis. These proteins protect the body against disease. The 2 major types of protein present in the serum are albumin and the globulin proteins.Īlbumin is the major protein component of serum and represents the largest peak that lies closest to the positive electrode. Procedure Preparation Risks Results What is an immunofixation-serum test Immunoglobulins (Ig) are also known as antibodies. Serum protein electrophoresis (SPEP) is an easy, inexpensive method of separating proteins based on their net charge, size, and shape. ![]()
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